Von Willebrand factor antigen as a marker of disease activity in childhood-onset antineutrophil cytoplasmic antibody–associated vasculitis
Main finding · VWF antigen levelResult — go to the resultOdds ratio 3.01 95% CI 2.3–3.93Authors' conclusion
Increased VWF antigen levels correlate with active vasculitis in this paediatric-onset AAV cohort
Study context
- Population
- Children with ANCA-associated vasculitis (AAV) with more than one Von Willebrand factor (VWF) level measured732 VWF measurements
- Participants
- 33 children
- Exposure
- Active vs inactive disease
- Outcome
- Relationship between VWF antigen and disease activity over time
Methodological detailsgeneralized estimating equations, repeated measures correlation, ROC analysis
- Generalized estimating equations
- Repeated measures correlation
- ROC analysis
Main finding
VWF antigen level
Odds ratio
3.01
95% CI 2.3–3.93
P < 0.001
By group
Active diseasevs Inactive disease
OR 3.01 (95% CI 2.3–3.93); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
VWF effect by disease subtype
- No substantial difference between disease subtypes
Correlation of VWF antigen with disease activity and diagnostic performance
- Moderate positive correlation, with acceptable sensitivity and specificity
Original publication
Von Willebrand factor antigen as a marker of disease activity in childhood-onset antineutrophil cytoplasmic antibody–associated vasculitis. Rheumatology (Oxford). Published 14 November 2023. doi:10.
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