Effective Performance of the 2022 American College of Rheumatology/ EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study
Authors' conclusion
The 2022 ACR/EULAR classification criteria for AAV perform at least as well as previous pediatric criteria and provide categorical MPA criteria where none existed previously; the criteria for GPA and MPA now specifically differentiate each other, with more differences between them in the frequencies of clinical features.
Study context
- Population
- Children with chronic small-to-medium vessel vasculitis in A Registry of Childhood Vasculitis (ARChiVe), identified by physician's diagnosis
- Participants
- 574 children
- Comparison
- 2022 American College of Rheumatology (ACR)/EULAR antibody-associated vasculitis (AAV) criteria vs Ped-EMA algorithm (incorporating Ankara granulomatosis with polyangiitis (GPA) criteria), against physician diagnosis
- Outcome
- Sensitivity and specificity of criteria for GPA against physician diagnosis
Methodological detailsregistry-based cohort, classification criteria validation
- Registry-based cohort
- Classification criteria validation
Performance
As reported in the abstract
Classification of GPA vs MD-diagnosis (ACR/EULAR vs Ankara criteria)
| Test or model | Sensitivity | Specificity |
|---|---|---|
| ACR/EULAR | 74.5% | 93.9% |
| Ped-EMA | 72.1% | 79.9% |
Sensitivity
ACR/EULAR74.5%
Ped-EMA72.1%
Specificity
ACR/EULAR93.9%
Ped-EMA79.9%
Further findings
GPA cases coclassified as MPA
Events
| Outcome | ACR/EULAR | Ped-EMA |
|---|---|---|
| Patients classified as GPA or MPA | 396 | 360 |
| Patients classified as GPA | 261 | 288 |
| Patients classified as MPA | 135 | 72 |
| PVAS-defined clinical features differing between GPA and MPAFisher exact test | 14 | 10 |
Original publication
Effective Performance of the 2022 American College of Rheumatology/ EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study. Arthritis Rheumatol. Published 9 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →