Evaluating Renal Disease in Pediatric‐Onset Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Disease Course, Outcomes, and Predictors of Outcome
Authors' conclusion
The majority of patients with pediatric AAV achieve inactive renal disease by 12 months; however, almost half have evidence of damage. Renal function at diagnosis is a strong predictor of renal function at 12 months.
Study context
- Population
- Pediatric-onset AAV (granulomatosis with polyangiitis (GPA), MPA or antineutrophil cytoplasmic antibody (ANCA)-positive pauci-immune glomerulonephritis), ≤18 years at diagnosis, with renal disease by biopsy or dialysis dependence; ARChiVe/PedVas registry68% female
- Participants
- 145 participants
- Exposure
- Kidney Disease Improving Global Outcomes (KDIGO) renal function category at diagnosis vs normal renal function
- Patientsn = 145
- Outcome
- Inactive renal disease (pediatric vasculitis activity score = 0 or 1)
- Follow-up
- 12 months
Methodological detailsambispective, proportional-odds logistic regression
- Ambispective
- Proportional-odds logistic regression
Main finding
As reported in the abstract
Patients
83%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Non-normal KDIGO category by renal function at diagnosis · 12 monthsModerate to severely reduced renal functionvs Normal renal functionProportional-odds logistic regression model | 8.62 (2.31–32.1) | P = 0.002 | |
| Non-normal KDIGO category by renal function at diagnosis · 12 monthsKidney failurevs Normal renal functionProportional-odds logistic regression model | 26.3 (6.32–109) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Patients |
|---|---|
| Permanent renal damage · 12 months | 42% |
Original publication
Evaluating Renal Disease in Pediatric‐Onset Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Disease Course, Outcomes, and Predictors of Outcome. Arthritis Rheumatol. Published 14 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →