Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus
Authors' conclusion
The observed trend of elevated NF-κB levels and decreased PPAR-γ levels in our study suggests their potential as biomarkers associated with increased proinflammatory signalling in jSLE and jSSc.
Study context
- Population
- Children with Juvenile SLE (jSLE), juvenile systemic sclerosis (jSSc) and age-matched healthy children
- Participants
- 42 / 19 / 25
- Exposure
- jSLE vs jSSc vs healthy controls
- jSLEn = 42
- jSScn = 19
- Healthy controlsn = 25reference
- Outcome
- Serum NF-κB and PPAR-γ levels (immunoassay) as biomarkers for jSLE
Methodological detailsage-matched healthy controls, patient control (jSSc)
- Age-matched healthy controls
- Patient control (jSSc)
Main finding
As reported in the abstract
OR, PPAR-γ <2.42 ng/mL
7.59
jSLE
OR, PPAR-γ <2.16 ng/mL
10.90
jSSc
- Combined high NF-κB with low PPAR-γ increased risk of developing jSSc (fold)
- 21.33
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| NF-κB levels in jSLE with vs without cumulative damage (PedSDI≥1)Significantly higher | P = 0.044 |
Original publication
Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus. Lupus Sci Med. Published 8 January 2025. doi:10.
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