Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study
Authors' conclusion
Patients with unifocal CNO involvement at diagnosis were more likely to require shorter NSAID treatment. Patients with more regions affected and those with symmetric bone lesions were more likely to require second-line treatment.
Study context
- Population
- Children with chronic nonbacterial osteomyelitis (CNO) attending a CNO clinic at a quaternary care center, 1/1/05–7/31/21
- Participants
- 164 children
- Exposure
- NSAID monotherapy response vs requiring second-line treatment
- NSAID-shortn = 32
- NSAID-longn = 62
- Second-line treatmentn = 70
- Outcome
- Clinical variables associated with NSAID monotherapy response vs requiring second-line medication (total NSAID monotherapy days; odds of needing second-line treatment)
Methodological detailssingle-centre, multiple linear and logistic regression
- Single-centre
- Multiple linear and logistic regression
Main finding
As reported in the abstract
Unifocal vs multifocal disease at diagnosis: fewer days of NSAIDs (NSAID groups)
47%
Odds of needing second-line treatment per additional region affected (p = 0.01)
1.94 times
Symmetric bone lesions: more likely to require second-line treatment (p < 0.001)
6.86 times
Observational data: associations, not effects.
Original publication
Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study. Pediatr Rheumatol Online J. Published 3 January 2025. doi:10.
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