Acute phase reactants in paediatric chronic nonbacterial osteomyelitis: implications for diagnosis and correlation with disease phenotype
Authors' conclusion
Markedly elevated APRs are observed in a substantial subset of CNO patients that may cause classification limitations. These patients show more severe systemic inflammation, more extensive involvement, particularly in clavicle, pelvis and sacroiliac joints, and a higher likelihood of CNO-associated diseases.
Study context
- Population
- Paediatric patients diagnosed with chronic nonbacterial osteomyelitis (CNO)
- Participants
- 51 patients
- Exposure
- Markedly elevated acute phase reactants (APRs) vs normal-to-moderately elevated APRs at diagnosis
- Markedly elevated APRsn = 16
- Outcome
- Proportion with markedly elevated APRs at diagnosis
- Follow-up
- Diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Markedly elevated APRs
31%
16
Observational data: associations, not effects.
Original publication
Acute phase reactants in paediatric chronic nonbacterial osteomyelitis: implications for diagnosis and correlation with disease phenotype. Rheumatology (Oxford). Published 9 September 2026. doi:10.
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