Therapeutic plasma exchange in paediatric ANCA-associated vasculitis: a multicentre real-world experience
Authors' conclusion
Although disease activity and acute organ-threatening manifestations improved following TPE, persistent renal abnormalities remained frequent, reflecting the severity of baseline kidney disease.
Study context
- Population
- Children (<18 years) with antibody-associated vasculitis (AAV) according to EULAR/PRINTO/PRES criteria
- Participants
- 26 children
- Exposure
- Therapeutic plasma exchange (TPE)-treated vs non-TPE-treated paediatric AAV
- TPE+n = 11
- Outcome
- PVAS before vs after TPE (TPE+)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Significant reduction in Paediatric Vasculitis Activity Score (PVAS) with TPE (median 12.0-4.5)
- P = 0.007
Observational data: associations, not effects.
Further findings
Median
| Outcome | TPE+ | TPE- | P value |
|---|---|---|---|
| Disease activity at diagnosis (PVAS) | 12 | 7 | P = 0.004 |
Disease activity at diagnosis (PVAS)
- More severe kidney involvement in TPE+, with higher serum creatinine and lower eGFR
Death from catheter-related Pseudomonas aeruginosa sepsis during treatment
- One patient died
- 1
Original publication
Therapeutic plasma exchange in paediatric ANCA-associated vasculitis: a multicentre real-world experience. Rheumatology (Oxford). Published 9 September 2026. doi:10.
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