Clinical spectrum and outcome of Takayasu's arteritis in children
Authors' conclusion
Paediatric TAK seems more severe than adult TAK.
Study context
- Population
- Children and adults with TAK in a European population, nationwide, 1988–2019
- Participants
- 46 vs 389
- Exposure
- Children vs adults with TAK
- Childrenn = 46
- Adultsn = 389reference
- Outcome
- Clinical spectrum and outcome, children vs adults
Methodological detailsnationwide, observational
- Nationwide
- Observational
Main finding
As reported in the abstract
- Adults: more upper limb claudication
- P<0.01
- Adults: more damage at cerebral vasculature
- P<0.01
- Adults: more damage at upper and lower limbs
- P<0.001
- Children: more kidney lesions
- P<0.05
- Children: more frequent biological inflammation
- P<0.01
- Children: higher biological inflammation
- P<0.001
- Children: higher dose-weight of GC at diagnosis
- P=0.001
- Children: less biotherapy at diagnosis
- P<0.010
- Relapses more frequent in children
- P<0.05
Observational data: associations, not effects.
Further findings
Death
| Outcome | Children | Adults | P value |
|---|---|---|---|
| Male to female ratio | 0.74 | 0.88 | P < 0.05 |
| Male/female | 34/46 | 241/274 |
Original publication
Clinical spectrum and outcome of Takayasu's arteritis in children. Joint Bone Spine. Published 15 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →