C-reactive protein to albumin ratio as a prognostic tool for predicting intravenous immunoglobulin resistance in children with kawasaki disease: a systematic review of cohort studies
Authors' conclusion
CAR is an auxiliary predictive indicator with moderate diagnostic value that provides guidance in the early treatment of the disease, demonstrating a certain predictive value that warrants further investigation. However, CAR cannot yet be considered as a definitive diagnostic or exclusionary marker for IVIG-resistant KD.
Study context
- Population
- Children with Kawasaki disease (KD) treated with intravenous immunoglobulin (IVIG)4 studies
- Outcome
- Accuracy of CAR for predicting IVIG-resistant KD
Methodological detailsdiagnostic accuracy, random-effects model, QUADAS-2.0 quality assessment
- Diagnostic accuracy
- Random-effects model
- QUADAS-2.0 quality assessment
Pooled result
As reported in the abstract
Pooled accuracy of CAR for predicting IVIG-resistant KD
| Group | Sensitivity | Specificity | AUC | Positive likelihood ratio | Negative likelihood ratio | Diagnostic OR |
|---|---|---|---|---|---|---|
| CAR | 0.65 (95% CI 0.58-0.72) | 0.71 (95% CI 0.57-0.81) | 0.70 (95% CI 0.66-0.74) | 2.22 (95% CI 1.35-3.65) | 0.49 (95% CI 0.35-0.69) | 5 (95% CI 2-10) |
CAR
Sensitivity0.65 (95% CI 0.58-0.72)
Specificity0.71 (95% CI 0.57-0.81)
AUC0.70 (95% CI 0.66-0.74)
Positive likelihood ratio2.22 (95% CI 1.35-3.65)
Negative likelihood ratio0.49 (95% CI 0.35-0.69)
Diagnostic OR5 (95% CI 2-10)
Original publication
C-reactive protein to albumin ratio as a prognostic tool for predicting intravenous immunoglobulin resistance in children with kawasaki disease: a systematic review of cohort studies. Pediatr Rheumatol Online J. Published 12 April 2024. doi:10.
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