Uveitis treatment in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: response to tumour necrosis factor inhibitors
Authors' conclusion
White race and non-oligoarticular JIA were associated with a successful response to TNFi.
Study context
- Population
- CARRA Registry subjects aged 0–25 with JIA-associated uveitis (onset before age 19) who ever used TNFimet inclusion criteria
- Participants
- 558 subjects
- Outcome
- Successful treatment (response) under TNFi and associated factors
Methodological detailsregistry-based (CARRA Registry), multivariable logistic regression
- Registry-based (CARRA Registry)
- Multivariable logistic regression
Main finding
As reported in the abstract
Successful treatment under TNFi
- Successful treatment under TNFi
- 418 (74.9%)
- TNFi non-responders
- 140 (25.1%)
- Non-responders who remained on TNFi
- 117
- Non-responders who discontinued TNFi
- 23
- Association of White race with TNFi success (multivariate)
- OR=2.08, p=0.005
- Association of non-oligoarticular JIA with TNFi success (multivariate)
- OR=1.58, p=0.044
Observational data: associations, not effects.
Further findings
TNFi use among JIA-U subjects
- Used TNFi, of 871 JIA-U subjects
- 616 (70.7%)
Original publication
Uveitis treatment in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: response to tumour necrosis factor inhibitors. Clin Exp Rheumatol. Published 10 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →