Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study
Main finding · Active disease (cJADAS-10)Result — go to the resultAdjusted odds ratio 2.10 95% CI 1.73–2.53Authors' conclusion
Cumulative social disadvantage is strongly associated with active JIA and mediates much of the effect of neighborhood disadvantage.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry (2015–2022)median follow-up 2.1 years
- Participants
- 9,609 children
- Exposure
- Cumulative social disadvantage score 3 vs 0
- Outcome
- Active disease by cJADAS-10
Methodological detailsregistry-based, mixed effects models, causal mediation analysis
- Registry-based
- Mixed effects models
- Causal mediation analysis
Main finding
Active disease (cJADAS-10)
Adjusted odds ratio
2.10
95% CI 1.73–2.53
Score 3vs Score 0
aOR 2.10 (95% CI 1.73–2.53)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prevalence of cumulative social disadvantage score >0
- Score >0, with higher scores correlating with greater neighbourhood disadvantage
- 39.1%
Proportion of neighbourhood disadvantage effect mediated through cumulative social disadvantage
- Proportion mediated
- 87% (95% CI 38-100)
- Causal mediation analysis
Original publication
Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study. Arthritis Care Res (Hoboken). Published 30 April 2026. doi:10.
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