Racial Disparities and Achievement of the Low Lupus Disease Activity State: A Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Study
Main finding · LLDAS achievementResult — go to the resultAdjusted odds ratio 0.56 95% CI 0.38–0.82Authors' conclusion
Children with cSLE who identified as Black are less likely to achieve LLDAS and have a higher disease activity. Living in areas of higher ADI may relate to renal disease and subsequent prednisone exposure.
Study context
- Population
- Children with childhood-onset SLE (cSLE) in the CARRA Registry
- Participants
- 540 children
- Exposure
- Self-reported race and ethnicity and low lupus disease activity state (LLDAS) achievement
- Outcome
- Achievement of LLDAS
Methodological detailsregistry-based, multivariable regression adjusted for disease-related and demographic factors
- Registry-based
- Multivariable regression adjusted for disease-related and demographic factors
Main finding
LLDAS achievement
Adjusted odds ratio
0.56
95% CI 0.38–0.82
Blackvs White
aOR 0.56 (95% CI 0.38–0.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Residence in highest-ADI neighborhoods
| Outcome | Adjusted β (95% CI) |
|---|---|
| Disease activity | 0.94 (0.11–1.78) |
Highest area deprivation index (ADI) and LLDAS achievement
- Highest ADI not associated with lower LLDAS achievement after adjustment for renal disease and insurance
Renal disease as mediator of ADI–prednisone exposure association
- Renal disease a significant mediator
- P = 0.04
Original publication
Racial Disparities and Achievement of the Low Lupus Disease Activity State: A CARRA Registry Study. Arthritis Care Res (Hoboken). Published 22 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →