Clinical utility of CBC-Derived inflammatory markers for predicting intravenous immunoglobulin (IVIG) resistance: findings from a Korean infant Kawasaki disease cohort
Authors' conclusion
MLR demonstrated moderate discriminative ability for predicting IVIG resistance in infant KD, suggesting its potential as a simple, cost-effective tool for early risk stratification in this vulnerable population.
Study context
- Population
- Infants under 12 months with Kawasaki disease, diagnosed January 2014–December 2024 (Korean cohort)67 IVIG-resistant (25.7%)
- Participants
- 261 participants
- Exposure
- CBC-derived inflammatory markers for predicting IVIG resistance
- Outcome
- IVIG resistance
Methodological detailsROC curve analysis, multivariate logistic regression
- ROC curve analysis
- Multivariate logistic regression
Main finding
As reported in the abstract
Predictive accuracy for IVIG resistance (AUC)
| Group | AUC | 95% CI |
|---|---|---|
| Monocyte-to-lymphocyte ratio (MLR) | 0.776 | 0.706-0.845 |
| Neutrophil-to-lymphocyte ratio (NLR) | 0.738 | 0.670-0.806 |
| PIV | 0.734 | 0.658-0.811 |
AUC
Monocyte-to-lymphocyte ratio (MLR)0.776
Neutrophil-to-lymphocyte ratio (NLR)0.738
PIV0.734
95% CI
Monocyte-to-lymphocyte ratio (MLR)0.706-0.845
Neutrophil-to-lymphocyte ratio (NLR)0.670-0.806
PIV0.658-0.811
Observational data: associations, not effects.
Further findings
Independent predictors of IVIG resistance (multivariate analysis)
| OR (95% CI) | ||
|---|---|---|
| MLR > 0.21 | 3.45 (1.66–7.14) | |
| PIV > 726.68 | 2.30 (1.14–4.67) | |
| Elevated total bilirubin | 1.96 (1.02–3.79) | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Proportion | P value |
|---|---|---|
| Coronary artery aneurysms, IVIG-resistant vs not | 16.4% vs. 5.2% | P = 0.007 |
Original publication
Clinical utility of CBC-Derived inflammatory markers for predicting IVIG resistance: findings from a Korean infant Kawasaki disease cohort. Pediatr Rheumatol Online J. Published 18 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →