A novel scoring system based on sIL-2R for predicting intravenous immunoglobulin (IVIG) resistance in Chinese children with Kawasaki disease (KD)
Authors' conclusion
Our newly developed scoring system utilizing sIL-2R demonstrated superior predictive performance in identifying IVIG resistance among Chinese patients with KD.
Study context
- Population
- Chinese children with Kawasaki disease treated at a cardiovascular medical ward, January 2020 to December 202242 IVIG-resistant
- Participants
- 521 children
- Exposure
- Novel sIL-2R-based score vs Egami, Formosa, Harada, Kobayashi, Lan and Yang scores for predicting IVIG resistance
- Outcome
- Prediction of resistance to IVIG (sensitivity and specificity)
Methodological detailssingle-centre, development of a predictive scoring system, comparison with six established scoring systems
- Single-centre
- Development of a predictive scoring system
- Comparison with six established scoring systems
Main finding
As reported in the abstract
Prediction of IVIG resistance: sensitivity and specificity
| Group | Sensitivity | Specificity |
|---|---|---|
| Novel sIL-2R score | 69.29% | 83.91% |
| Egami | 38.10% | 88.52% |
| Formosa | 95.24% | 41.13% |
| Harada | 78.57% | 43.22% |
| Kobayashi | 66.67% | 74.95% |
| Lan | 66.67% | 73.49% |
| Yang | 69.05% | 77.24% |
Sensitivity
Novel sIL-2R score69.29%
Egami38.10%
Formosa95.24%
Harada78.57%
Kobayashi66.67%
Lan66.67%
Yang69.05%
Specificity
Novel sIL-2R score83.91%
Egami88.52%
Formosa41.13%
Harada43.22%
Kobayashi74.95%
Lan73.49%
Yang77.24%
Observational data: associations, not effects.
Further findings
IVIG resistance incidence
- IVIG-resistant KD patients
- 42 (8.06%)
Coronary arterial lesions in IVIG-resistant KD patients
- IVIG-resistant patients at increased risk of coronary arterial lesions (CALs)
- P = 0.001
Original publication
A novel scoring system based on sIL-2R for predicting IVIG resistance in Chinese children with KD. Pediatr Rheumatol Online J. Published 18 August 2024. doi:10.
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