C-reactive protein to high density lipoprotein cholesterol ratio for predicting coronary artery lesions, and intravenous immunoglobulin resistance in Kawasaki disease
Main findingResult — go to the resultZ 7.146Authors' conclusion
Children with KD who developed either CAL or IVIG resistance exhibited significantly higher CRP/HDL-C ratios.
Study context
- Population
- Children with Kawasaki disease hospitalized at Qilu Hospital, January 2016 to July 2023
- Participants
- 203 children
- Exposure
- Kawasaki disease (KD) with coronary artery lesion (CAL) vs KD without CAL; Intravenous immunoglobulin (IVIG)-resistant vs IVIG-sensitive
- KD-CALn = 87
- KD-nonCALn = 116reference
- IVIG-resistancen = 28
- IVIG-sensitiven = 175reference
- Outcome
- CRP/HDL-C ratio as a predictor of CAL and IVIG resistance
Methodological detailssingle-centre, ROC curve analysis
- Single-centre
- ROC curve analysis
Main finding
As reported in the abstract
Z
7.146
P < 0.001
By group
KD-CAL
159.94
median · IQR 57.07–225.63
KD-nonCAL
54.89
median · IQR 19.50–81.19
- Sensitivity for diagnosing CAL
- 55.2%
- Specificity for diagnosing CAL
- 87.1%
- AUC for diagnosing CAL (P < 0.001)
- 0.793
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Incidence of CALIVIG-resistance vs IVIG-sensitive · significantly higher in IVIG-resistant | χ² 4.229 | P = 0.04 |
| CRP/HDL-C ratio and its accuracy for predicting IVIG resistanceIVIG-resistance vs IVIG-sensitive · ratio significantly elevated in IVIG-resistant | Z 2.162 | P = 0.031 |
- CRP/HDL-C ratio and its accuracy for predicting IVIG resistance — Sensitivity for predicting IVIG resistance
- 46.4%
- CRP/HDL-C ratio and its accuracy for predicting IVIG resistance — Specificity for predicting IVIG resistance
- 84.6%
- CRP/HDL-C ratio and its accuracy for predicting IVIG resistance — AUC for predicting IVIG resistance (P = 0.031)
- 0.627
CRP and HDL-C levels
- KD-CAL had significantly elevated CRP and lower HDL-C than KD-nonCAL (P < 0.001)
Original publication
C-reactive protein to high density lipoprotein cholesterol ratio for predicting coronary artery lesions, and intravenous immunoglobulin resistance in Kawasaki disease. Pediatr Rheumatol Online J. Published 29 October 2025. doi:10.
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