Risk factors and long-term follow-up in acute Kawasaki disease patients with medium or large coronary artery aneurysms
Authors' conclusion
Days to initial IVIG treatment, IVIG resistance, albumin levels and platelet count were risk factors for KD patients with medium or large CAA. The prognosis of medium or large CAA is not ideal during a long-term follow-up, particularly for large CAA.
Study context
- Population
- Chinese cohort of children with kawasaki disease (KD), January 2015 to April 2020followed up >12 months
- Participants
- 220 participants
- Exposure
- KD with medium or large CAA vs KD without coronary artery abnormality
- Medium or large CAAn = 55
- No coronary artery abnormalityn = 165reference
- Outcome
- Risk factors for medium or large CAA in KD
Methodological detailsunivariate and multivariate logistic regression
- Univariate and multivariate logistic regression
Main finding
As reported in the abstract
Independent risk factors for medium or large CAA (multivariate logistic regression)
- Days to initial IVIG treatment, IVIG resistance, albumin level and platelet count were independent risk factors
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Regression to normal coronary artery diameter, medium CAA subgroup · mean follow-up 49 months | Medium CAA 54.3% · small CAA 31.4% · medium CAA 8.6% · large CAA 5.7% |
| Regression to normal coronary arteries, large CAA subgroup · mean follow-up 49 months | Large CAA 0 events · small CAA 15.0% · medium CAA 25.0% · large CAA 60.0% |
Safety
- Coronary thrombosis, acute phase — Medium or large CAA
- 20.0%
- Coronary thrombosis, end of follow-up — Medium or large CAA
- 32.7%
- Coronary thrombosis, acute phase: Medium CAA 2 events
- Coronary thrombosis, acute phase: Large CAA 9 events
- Coronary thrombosis, end of follow-up: Medium CAA 5 events
- Coronary thrombosis, end of follow-up: Large CAA 13 events
Original publication
Risk factors and long-term follow-up in acute Kawasaki disease patients with medium or large coronary artery aneurysms. Clin Exp Rheumatol. Published 22 October 2025. doi:10.
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