Clinical outcomes of giant coronary aneurysms in South Asian children with Kawasaki disease
Authors' conclusion
Delayed diagnosis and treatment intensification may have contributed to mixed outcomes in this GCAA cohort.
Study context
- Population
- Children with kawasaki disease (KD)-associated giant coronary artery aneurysms (GCAAs) (z-score >10 or diameter >8mm), referred with documented IVIg resistance, treated 2019–2024 at a tertiary care center in Kerala, Indiatwo lost-to-follow-up
- Participants
- 18 children
- Outcome
- GCAA dimension change
- Follow-up
- Last
Methodological detailssingle tertiary care centre
- Single tertiary care centre
Main finding
As reported in the abstract
median follow-up 8.6 (5.2 - 19.4) months
Complete GCAA resolution
three (18.8%)
Reduction to small/medium aneurysms
six (37.6%)
Remained static
five (31.3%)
Observational data: associations, not effects.
Secondary outcomes
Anticoagulation discontinued (children whose aneurysms resolved or reduced significantly)
- Anticoagulation discontinued
- 56.25%
Delayed diagnosis (>10 days after symptom onset)
- Delayed diagnosis
- ten (55%)
- Median diagnosis, days
- 11 (IQR 7 - 13.5)
- All faced delays in treatment intensification
Mortality
- Death from MI
- One (6.3%)
Safety
Coronary artery bypass grafting
- Patient requiring CABG
- 1
Original publication
Clinical outcomes of giant coronary aneurysms in South Asian children with Kawasaki disease. Pediatr Rheumatol Online J. Published 29 December 2025. doi:10.
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