Comparison of EULAR/PRINTO/Pediatric Rheumatology European Society (PReS) Ankara 2008 and 2022 ACR/EULAR classification criteria for granulomatosis with polyangiitis in children
Authors' conclusion
In children, both the ACR/EULAR and EULAR/PRINTO/PReS Ankara 2008 classification criteria for GPA perform well and similarly.
Study context
- Population
- Paediatric patients with granulomatosis with polyangiitis (GPA) (diagnosis by expert opinion) and controls with other vasculitides, 20 centres in 9 countries77 GPA, 108 controls
- Comparison
- 2022 ACR/EULAR vs EULAR/PRINTO/PReS Ankara 2008 classification criteria for GPA
- Outcome
- Sensitivity, specificity, PPV and NPV of the criteria sets
Methodological detailsretrospective, multicentre (20 centres, 9 countries)
- Retrospective
- Multicentre (20 centres, 9 countries)
Performance
As reported in the abstract
Performance of classification criteria for GPA
| Test or model | Value | Sensitivity | Specificity |
|---|---|---|---|
| Ankara 2008 criteria | 73 events | 94.8% | 95.3% |
| ACR/EULAR classification criteria | 69 events | 89.6% | 96.3% |
Value
Ankara 2008 criteria73 events
ACR/EULAR classification criteria69 events
Sensitivity
Ankara 2008 criteria94.8%
ACR/EULAR classification criteria89.6%
Specificity
Ankara 2008 criteria95.3%
ACR/EULAR classification criteria96.3%
- ACR/EULAR classification criteria vs Ankara 2008 criteria: P = 0.229 — No significant difference
- ACR/EULAR classification criteria vs Ankara 2008 criteria: P = 0.733 — No significant difference
Further findings
Most common presentations in GPA
- Constitutional symptoms
- 85.7%
- ENT involvement
- 79.2%
Original publication
Comparison of EULAR/PRINTO/PReS Ankara 2008 and 2022 ACR/EULAR classification criteria for granulomatosis with polyangiitis in children. Rheumatology (Oxford). Published 22 December 2023. doi:10.
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