Association of persistent oxidative stress markers with coronary artery abnormalities in Kawasaki disease patients on follow-up
Authors' conclusion
Children with KD exhibit persistent oxidative stress during follow-up, as evidenced by increased neutrophil ROS production, indicating ongoing cellular oxidative activity.
Study context
- Population
- Children with kawasaki disease (KD) on follow-up62 KD children and 20 healthy controls (HC)
- Exposure
- KD patients at different follow-up durations, with and without coronary artery abnormalities (CAAs), vs healthy controls
- HCn = 20reference
- Outcome
- Extracellular nitric oxide metabolites (serum nitrite and nitrate) and neutrophil ROS, and their associations with CAAs
Methodological detailssingle-centre, age- and gender-matched healthy controls
- Single-centre
- Age- and gender-matched healthy controls
Main finding
As reported in the abstract
Serum nitrite
Group 1
3.46
± 1.64
Group 2
5.04
± 2.55
Group 3
5.22
± 3.00
HC
3.33
± 1.98
P = 0.06
Observational data: associations, not effects.
Further findings
| Outcome | Group 1 | Group 2 | Group 3 | HC | P value |
|---|---|---|---|---|---|
| Serum nitrateGroups 1-3 vs HC · comparable | 63.07 ± 41.32 | 58.63 ± 27.12 | 64.57 ± 26.36 | 57.49 ± 8.68 | P = 0.43 |
- Serum nitrate, KD with vs without CAAs (subgroup)
- P = 0.60
- Serum nitrate, KD with vs without CAAs (subgroup)
- P > 0.99
- Serum nitrate, KD with vs without CAAs (subgroup)
- P = 0.10
- Serum nitrite, KD with vs without CAAs (subgroup)
- P > 0.99
- Serum nitrite, KD with vs without CAAs (subgroup)
- P > 0.99
- Serum nitrite, KD with vs without CAAs (subgroup)
- P = 0.90
- Neutrophil reactive oxygen species (ROS) production (ΔMFI) · Group 2 vs HC · significant rise in Group 2
- P = 0.03
Serum nitrate, KD with vs without CAAs (subgroup)
- Comparable with and without CAAs
Serum nitrite, KD with vs without CAAs (subgroup)
- Comparable with and without CAAs
Neutrophil ROS production (ΔMFI)
- Increased in KD patients
Correlation of oxidative stress markers with systemic inflammatory parameters
- No significant correlations
Original publication
Association of persistent oxidative stress markers with coronary artery abnormalities in Kawasaki disease patients on follow-up. Pediatr Rheumatol Online J. Published 4 September 2026. doi:10.
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