Treatment responses and relapse predictors in paediatric chronic nonbacterial osteomyelitis (CNO): insights from a referral centre
Main finding · Predictors of relapse (multivariate analysis)Result — go to the resultOdds ratio 1.20 95% CI 1.03–1.39Authors' conclusion
Conventional DMARDs are effective in a limited subset of CNO patients, who may represent a milder disease phenotype. The presence of skin involvement and a greater number of affected bones may both suggest a more aggressive disease course.
Study context
- Population
- Patients diagnosed with chronic nonbacterial osteomyelitis (CNO) between 2020 and 2025 per EULAR/ACR classification criteria, tertiary referral centre
- Participants
- 80 patients
- Outcome
- Predictors of relapse (multivariate analysis)
Methodological detailssingle referral centre
- Single referral centre
Main finding
As reported in the abstract
Odds ratio
1.20
95% CI 1.03–1.39
P = 0.017
Number of bones involved
OR 1.20 (95% CI 1.03–1.39); P = 0.017
- Skin involvement
- 27.5%
- Response to NSAID monotherapy
- 5
- DMARDs used in 68 patients; clinical remission
- 11
- Pamidronate given to 20 patients; complete remission
- 3
Observational data: associations, not effects.
Original publication
Treatment responses and relapse predictors in paediatric CNO: insights from a referral centre. Rheumatology (Oxford). Published 3 December 2025. doi:10.
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