Validation of Patient‐Reported Outcomes Measurement Information System ( Patient-Reported Outcomes Measurement Information System (PROMIS) ) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis
Authors' conclusion
This study provided evidence supporting the use of PROMIS Pediatric mobility, PB, and PI measures for CNO clinical disease monitoring.
Study context
- Population
- English-speaking patients aged 8 years and older with chronic nonbacterial osteomyelitis (CNO) in a longitudinal patient registrymore than 1,000 clinical visits
- Participants
- 184 patients
- Outcome
- Validity of PROMIS Pediatric measures (fatigue, pain interference, pain behavior, mobility, upper extremity, physical activity, strength impact)
Methodological detailslongitudinal patient registry, linear mixed-effects models, Spearman rank correlation
- Longitudinal patient registry
- Linear mixed-effects models
- Spearman rank correlation
Performance
As reported in the abstract
Validity of PROMIS Pediatric measures
- All PROMIS T-scores correlated significantly with patient-reported variables and physician global assessment (PHGA)
- P < 0.01
- Correlation between function and mobility, pain behavior (PB) and pain interference (PI) good
- r = 0.4-0.6
- Correlation of patient-reported disease status with PHGA strong
- r = 0.75
- Changes of PROMIS T-scores over time for mobility, PB, physical activity (PA) and PI vs self-reported status change significant
- P < 0.05
- After effective treatment (clinical disease activity score improved by ≥3 points, n = 18), change of PROMIS T-scores for mobility, PB, PI and upper extremity (UE) significant
- P < 0.05
Original publication
Validation of Patient‐Reported Outcomes Measurement Information System ( PROMIS ) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis. Arthritis Care Res (Hoboken). Published 25 August 2026. doi:10.
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