EULAR /American College of Rheumatology Classification Criteria for Pediatric Chronic Nonbacterial Osteomyelitis
Authors' conclusion
These new classification criteria for pediatric CNO developed with international input reflect current views about CNO, have high specificity and good sensitivity, and provide a key foundation for future CNO research.
Study context
- Population
- Patients with pediatric chronic nonbacterial osteomyelitis (CNO); international initiative
- Participants
- 441 vs 514
- Comparison
- Development vs Validation
- Developmentn = 441
- Validationn = 514
- Outcome
- Sensitivity and specificity of the EULAR/American College of Rheumatology (ACR) classification criteria for CNO
Methodological detailsinternational, survey, Delphi and nominal group technique, multicriteria decision analysis, development and validation cohorts
- International
- Survey
- Delphi and nominal group technique
- Multicriteria decision analysis
- Development and validation cohorts
Performance
As reported in the abstract
Performance of the new EULAR/ACR CNO classification criteria (total score ≥55)
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Validation | 82% | 98% |
Validation
Sensitivity82%
Specificity98%
- Additive weighted criteria in 5 clinical and 4 pathology/laboratory domains; total score for classification as CNO
- ≥55
Original publication
EULAR /American College of Rheumatology Classification Criteria for Pediatric Chronic Nonbacterial Osteomyelitis. Arthritis Rheumatol. Published 8 May 2025. doi:10.
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