Development and validation of minimal disease activity, disease flare, and minimal clinically important difference for children with chronic nonbacterial osteomyelitis using a consensus and data-driven approach
Authors' conclusion
This study provides the preliminary definitions of MDA, disease flare, and MCID in CNO, which can serve as targets and potential outcomes from treatments.
Study context
- Population
- Children with chronic nonbacterial osteomyelitis (CNO); three cohorts' samples from an international observational CNO registry, panel of 20 CNO experts incl. 7 patients/caregiversexpert panel incl
- Participants
- 20 children
- Outcome
- Definitions of MDA, flare and MCID for CNO
Methodological detailsinternational observational registry, group consensus voting technique, online and in-person voting, consensus of ≥80%
- International observational registry
- Group consensus voting technique
- Online and in-person voting
- Consensus of ≥80%
Recommendations
As reported in the abstract
Definitions of MDA, flare and MCID
Clinical improvement in critical parameters considered meaningful
≥30%
Improvement of CNO Clinical Disease Activity Score considered meaningful
at least 3
Original publication
Development and validation of minimal disease activity, disease flare, and minimal clinically important difference for children with chronic nonbacterial osteomyelitis using a consensus and data-driven approach. Ann Rheum Dis. Published 8 August 2026. doi:10.
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