Research definitions of flare in non-systemic juvenile idiopathic arthritis: An OMERACT scoping review
Authors' conclusion
In JIA clinical research, "flare" is a common, but inconsistently defined, outcome.
Study context
- Population
- Peer-reviewed clinical research publications using "flare" as an outcome in patients of any age with non-systemic juvenile idiopathic arthritis (JIA)articles analysed
- Participants
- 139 participants
- Outcome
- Flare definitions used in non-systemic JIA clinical research
Methodological detailsOMERACT, seven databases searched, Search performed on 30 June 2024 and updated on 30 November 2025
- OMERACT
- Seven databases searched
- Search performed on 30 June 2024 and updated on 30 November 2025
Main finding
As reported in the abstract
Flare definitions
- Distinct approaches to measure flare
- 13
- Different interpretations of flare
- 39
- Definitions based on ACR Core Response Variables (CRV)
- 27%, n = 37/139
- Definitions based on Wallace Criteria
- 24%, n = 33/139
- Different interpretations using CRV approach
- nine
- Disease activity scores used to define flare
- 9%, n = 12/139
- Flare identified by patient or caregiver assessment
- 4% (n = 5/139)
- Articles published within the last five years
- 49% (n = 67/139)
Original publication
Research definitions of flare in non-systemic juvenile idiopathic arthritis: An OMERACT scoping review. Semin Arthritis Rheum. Published 8 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →