Synovial fibroblasts in juvenile idiopathic arthritis: A scoping review
Authors' conclusion
All included studies identified mechanisms potentially linking synovial fibroblasts to specific disease traits in juvenile idiopathic arthritis.
Study context
- Population
- Peer-reviewed studies on synovial fibroblasts from patients with JIAeligible studies of 1778 screened
- Participants
- 18 eligible studies
- Outcome
- Current knowledge on synovial fibroblasts in JIA
Methodological detailsMEDLINE, EMBASE and Web of Science, English-language peer-reviewed studies
- MEDLINE, EMBASE and Web of Science
- English-language peer-reviewed studies
Main finding
As reported in the abstract
- Most studies identified synovial fibroblast subsets or functional characteristics that may be involved in disease pathogenesis
- Mechanisms identified: cell-cell interaction with leukocytes, pro-inflammatory signaling and unfavorable connective tissue homeostasis that may contribute to cartilage damage or bony overgrowth
- All included studies identified mechanisms potentially linking synovial fibroblasts to specific disease traits in JIA
- Most findings similar to mechanisms described in synovial fibroblasts from adults with arthritis
Original publication
Synovial fibroblasts in juvenile idiopathic arthritis: A scoping review. Semin Arthritis Rheum. Published 24 December 2022. doi:10.
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