Soluble factors released from fibroblast-like synoviocytes of Juvenile Idiopathic Arthritis (JIA) patients with future extended course can condition persistent JIA synovial fibroblasts for increased IL-6 production
Authors' conclusion
Our findings suggest factors secreted by ETB FLS including IL-6 protein may contribute to disease extension.
Study context
- Population
- Oligoarticular JIA patients: synovial fluid samples and fibroblast-like synoviocytes (FLS) isolated from synovial fluid
- Comparison
- Extended-to-be vs persistent oligoarticular JIA: synovial fluid and FLS
- Outcome
- IL-6 and IL-6-related cytokines in synovial fluid and FLS
Methodological detailsprotein antibody arrays and ELISA, conditioned media experiments
- Protein antibody arrays and ELISA
- Conditioned media experiments
Main finding
As reported in the abstract
MANOVA Wilks’ λ
0.5446
P = 0.0136
F(9, 31) = 2.88; IL-6 and multiple IL-6-related cytokines significantly elevated in ETB synovial fluid
Fold increase
1.46
P = 0.047
synovial fluid IL-6 concentration, quantitative ELISA
Fold increase
1.6
P = 0.0239
IL-6 secretion by FLS isolated prior to extension
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Soluble factors released from fibroblast-like synoviocytes of JIA patients with future extended course can condition persistent JIA synovial fibroblasts for increased IL-6 production. Arthritis Res Ther. Published 7 March 2026. doi:10.
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