The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status
Authors' conclusion
Differences in the plasma NMR metabolomic profiles are apparent in children with sJIA, but not other JIA subtypes, relative to non-JIA controls.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) and non-JIA controls71 metabolomic biomarkers
- Participants
- 72 vs 18
- Exposure
- JIA vs non-JIA controls
- JIAn = 72
- Controlsn = 18reference
- Outcome
- Differences in the plasma metabolome between JIA patients and non-JIA controls, and markers of JIA subtype
Methodological detailstargeted nuclear magnetic resonance (NMR) metabolomics, multivariable linear regression
- Targeted NMR metabolomics
- Multivariable linear regression
Main finding
As reported in the abstract
Plasma metabolomic biomarkers, JIA vs controls (SD units)
JIA vs ControlsMean difference, standard deviations (95% CI)P value
GlycA (higher)
0.93(0.370–1.494)
Padj = 0.039Docosahexaenoic acid (higher)
1.06(0.51–1.60)
Padj = 0.021Acetate (lower)
−0.92(−1.43 to −0.41)
Padj = 0.024Observational data: associations, not effects.
Further findings
Biomarkers in systemic JIA (sJIA) vs controls (subgroup)
- Biomarkers significantly different (Padj <0.05) in sJIA relative to controls
- 24 of 71
oJIA and polyarticular JIA (RF positive or negative) vs controls (subgroups)
- No specific differences identified relative to controls
Glycoprotein acetyls (GlycA) and active disease in sJIA
- GlycA, but not high-sensitivity C-Reactive Protein (hsCRP), positively associated with active disease in sJIA
- 0.22, [−0.40, −0.04], Padj = 0.018
- Correlation of GlycA with hsCRP
- r > 0.70
sJIA-associated markers associated with inflammation markers
- sJIA-associated markers associated with GlycA levels
- 6 of 24
- sJIA-associated biomarkers associated with hsCRP levels (histidine)
- 1
Original publication
The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status. Pediatr Rheumatol Online J. Published 30 December 2024. doi:10.
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