Clinical, Immunologic, and Genetic Characteristics in Patients With Syndrome of Undifferentiated Recurrent Fevers
Authors' conclusion
Our findings suggest SURF is a heterogeneous group but has distinct clinical and immunologic features from disorders such as PFAPA.
Study context
- Population
- Patients observed at Cincinnati Children's Hospital Medical Center
- Participants
- 46 patients
- Exposure
- Syndrome of undifferentiated recurrent fevers (SURF) vs PFAPA
- Outcome
- Clinical features, SURF vs PFAPA
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Prevalence of rash and arthralgias higher in SURF vs PFAPA
- Pharyngitis and adenopathy less frequent in SURF
Observational data: associations, not effects.
Further findings
Cytokine signature
- A subset of SURF clustered with elevated proinflammatory cytokines and more frequently required biologic therapy
Genetic variants (whole exome sequencing)
- Variants of unknown clinical significance (VUCS) frequent in genes implicated in B cell development, immunodeficiencies and inflammatory bowel disease risk
Treatment
- SURF treatments commonly included on-demand steroids, colchicine and anti-IL-1 therapy
Original publication
Clinical, Immunologic, and Genetic Characteristics in Patients With Syndrome of Undifferentiated Recurrent Fevers. Arthritis Rheumatol. Published 29 December 2024. doi:10.
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