Hematological involvement in juvenile-onset systemic lupus erythematosus: Clinical features and its impact on disease management
Authors' conclusion
Hematological involvement was detected in approximately half of jSLE patients. Hypocomplementemia and positive Coombs test were more frequently observed in patients with hematological involvement.
Study context
- Population
- Patients with jSLE (2012 SLICC classification criteria) followed at a pediatric rheumatology clinic, January 2015–May 202548 (90.6%) female
- Participants
- 53 patients
- Exposure
- jSLE with vs without hematological involvement
- Hematological involvementn = 28
- Outcome
- Hematological involvement: clinical characteristics and treatment approaches
Methodological detailssingle-center, Median age at diagnosis 13 years (IQR: 11-15); median follow-up 26 months (IQR: 12-48)
- Single-center
- Median age at diagnosis 13 years (IQR: 11-15); median follow-up 26 months (IQR: 12-48)
Main finding
As reported in the abstract
Hematological involvement
Hematological involvement
52.8%
28
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Constitutional symptoms, hypocomplementemia, direct Coombs positivity: hematological involvement vs noneHematological involvement vs No hematological involvement | P = 0.003 |
| Constitutional symptoms, hypocomplementemia, direct Coombs positivity: hematological involvement vs noneHematological involvement vs No hematological involvement | P = 0.034 |
| Constitutional symptoms, hypocomplementemia, direct Coombs positivity: hematological involvement vs noneHematological involvement vs No hematological involvement | P = 0.039 |
| IVIG use: hematological involvement vs noneAdministered more frequently with hematological involvement | P = 0.010 |
- Constitutional symptoms, hypocomplementemia, direct Coombs positivity: hematological involvement vs none: constitutional symptoms; significantly higher with hematological involvement
- Constitutional symptoms, hypocomplementemia, direct Coombs positivity: hematological involvement vs none: hypocomplementemia; significantly higher with hematological involvement
- Constitutional symptoms, hypocomplementemia, direct Coombs positivity: hematological involvement vs none: direct Coombs positivity; significantly higher with hematological involvement
Cytopenia types among patients with hematological involvement (n=28)
- Anemia
- 18 (64.3%)
- Lymphopenia
- 16 (57.1%)
- Thrombocytopenia
- 14 (50.0%)
- Pancytopenia
- 4 (14.3%)
Time to improvement of cytopenia after treatment
- Median time to cytopenia improvement following treatment
- 32 days (IQR: 27-61)
Treatment basis in patients with hematological involvement
- Treatment based on isolated hematological findings
- 11
- Additional major organ involvement; treatment mainly directed by major organ manifestations
- 17
Original publication
Hematological involvement in juvenile-onset systemic lupus erythematosus: Clinical features and its impact on disease management. Lupus. Published 13 August 2026. doi:10.
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