Evaluating the Applicability of the EULAR/American College of Rheumatology (ACR) 2019, Systemic Lupus International Collaborating Clinics (SLICC) 2012, and ACR 1997 Classification Criteria for Systemic Lupus Erythematosus in Children: A Multicenter Study
Authors' conclusion
The EULAR/ACR 2019 criteria were the most appropriate for diagnosing cSLE.
Study context
- Population
- Children with cSLE, pediatric controls, adults with systemic lupus erythematosus (SLE) and adult controls, from 3 different regionscSLE 83.62% female · Children with cSLE 348 · pediatric controls 59 · adults with SLE 80 · adult controls 76
- Comparison
- EULAR/ACR 2019 vs SLICC 2012 vs ACR 1997 classification criteria for SLE in children
- Outcome
- Sensitivity, specificity and AUC of the classification criteria for cSLE
Methodological detailsmulticentre, cohort
- Multicentre
- Cohort
Performance
As reported in the abstract
Classification performance in children with SLE
| Test or model | AUC | Youden index | Sensitivity (highest) | Specificity (highest) |
|---|---|---|---|---|
| EULAR/ACR 2019 | 0.944 | 0.89 | ||
| SLICC 2012 | 94.54%, 95% CI 91.6-96.7% | |||
| ACR 1997 | 98.31%, 95% CI 90.9-100% |
AUC
EULAR/ACR 20190.944
SLICC 2012— not stated in the abstract
ACR 1997— not stated in the abstract
Youden index
EULAR/ACR 20190.89
SLICC 2012— not stated in the abstract
ACR 1997— not stated in the abstract
Sensitivity (highest)
EULAR/ACR 2019— not stated in the abstract
SLICC 201294.54%, 95% CI 91.6-96.7%
ACR 1997— not stated in the abstract
Specificity (highest)
EULAR/ACR 2019— not stated in the abstract
SLICC 2012— not stated in the abstract
ACR 199798.31%, 95% CI 90.9-100%
Further findings
Parallel testing (SLICC 2012 or EULAR/ACR 2019) for cSLE
- AUC (highest)
- 0.962
- Sensitivity
- 99.14%
EULAR/ACR 2019 score of 10 (cSLE cutoff)
- AUC (highest)
- 0.953, 95% CI 0.93-0.97
Original publication
Evaluating the Applicability of the EULAR/ACR 2019, SLICC 2012, and ACR 1997 Classification Criteria for Systemic Lupus Erythematosus in Children: A Multicenter Study. J Rheumatol. Published 15 December 2025. doi:10.
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