Hepatic Manifestations in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome
Authors' conclusion
This study underscores the critical roles of CD8+ T cells, macrophages, and IFN-γ in sJIA-MAS hepatitis.
Study context
- Population
- Patients with sJIA-MAS presenting with liver dysfunction who underwent core liver biopsies, Cincinnati Children's Hospital Medical Center (2019–2024)age range 4–15 years
- Participants
- 4 patients
- Outcome
- Liver pathology in sJIA-MAS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Elevated transaminases
4
Meeting macrophage activation syndrome (MAS) criteria
1
Subclinical MAS
3
Features of venoocclusive disease (novel finding)
1
Observational data: associations, not effects.
Original publication
Hepatic Manifestations in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome. J Rheumatol. Published 15 December 2025. doi:10.
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