The clinical features and outcome of Kawasaki disease combined with G6PD deficiency
Main finding · Persistent CAL beyond 8 weeksResult — go to the resultOdds ratio 2.21 95% CI 0.76–6.44Authors' conclusion
G6PD deficiency may not likely be a significantly risk factor for CAL in KD.
Study context
- Population
- Kawasaki disease patients with and without G6PD deficiency
- Participants
- 54 vs 162
- Comparison
- Kawasaki disease (KD) with G6PDd vs KD with normal G6PD activity
- G6PDdn = 54
- Controln = 162reference
- Outcome
- Persistent coronary artery lesions (CAL) beyond 8 weeks
- Follow-up
- Beyond 8 weeks
Methodological detailsmatched 1:3 by age, sex and hospitalization period
- Matched 1:3 by age, sex and hospitalization period
Main finding
Persistent CAL beyond 8 weeks
Odds ratio
2.21
95% CI 0.76–6.44
By group
G6PDdvs Control
OR 2.21 (95% CI 0.76–6.44)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | G6PDd | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| High-risk SANO classification (univariate analysis)Univariate analysis | 3.51 (1.60–7.72) | P = 0.002 | |||
| Non-SANO high-risk KD | 1.42 (0.60–3.35) | P = 0.420 | |||
| IVIG-resistant KD | 8.51% | 8.70% | 0.98 (0.31–3.12) | ||
| 0.10.31310Odds ratio (log scale) |
- Non-SANO high-risk KD — Similar proportion in both groups
- 16.67%
IVIG-resistant KD
- Prevalence comparable between the two groups
Original publication
The clinical features and outcome of Kawasaki disease combined with G6PD deficiency. Pediatr Rheumatol Online J. Published 12 December 2025. doi:10.
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