Superb microvascular imaging versus CT angiography for assessing disease activity in pediatric Takayasu arteritis: a comparative study with high consistency
Authors' conclusion
SMI and CTA demonstrate comparable diagnostic performance and high consistency in assessing disease activity in pediatric TA.
Study context
- Population
- Children with TAK treated at one hospital, May 2019–January 2025; active and inactive by National Institutes of Health (NIH) criteria26 active, 21 inactive · active 26 · inactive 21
- Participants
- 47 children
- Comparison
- Superb microvascular imaging (SMI) vs CT angiography (CTA) for assessing disease activity in pediatric TAK, against NIH criteria
- Outcome
- Sensitivity, specificity, accuracy and AUC of SMI grading and CTA for diagnosing TAK activity (reference: NIH criteria)
Methodological detailscomparative, single-centre
- Comparative
- Single-centre
Performance
As reported in the abstract
Diagnostic performance for TAK activity
| Test or model | AUC | Sensitivity | Specificity | Accuracy | Kappa vs NIH criteria |
|---|---|---|---|---|---|
| SMI | 0.885 | 84.62% | 95.24% | 89.36% | 0.788 |
| CTA | 0.895 | 88.46% | 90.48% | 89.36% | 0.786 |
AUC
SMI0.885
CTA0.895
Sensitivity
SMI84.62%
CTA88.46%
Specificity
SMI95.24%
CTA90.48%
Accuracy
SMI89.36%
CTA89.36%
Kappa vs NIH criteria
SMI0.788
CTA0.786
Further findings
SMI grading, active vs inactive
- SMI grading significantly higher in the active group than in the inactive group (Z = 5.388, p < 0.001)
Inter-observer agreement for SMI grading
- Kappa
- 0.865 (95% CI: 0.777-0.953)
- Complete concordance, 43 of 47 cases
- 91.49%
Original publication
Superb microvascular imaging versus CT angiography for assessing disease activity in pediatric Takayasu arteritis: a comparative study with high consistency. Pediatr Rheumatol Online J. Published 29 July 2026. doi:10.
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