Pediatric-onset Takayasu arteritis is associated with greater risk of mortality than adult-onset Takayasu arteritis–A systematic review with meta-analysis of observational cohort studies
Pooled result · DeathResult — go to the resultPooled relative risk 2.27 95% CI 1.05–4.85Authors' conclusion
An increased mortality risk with pediatric-onset TAK on meta-analysis is consistent with more frequent severe organ manifestations of pediatric-onset TAK (heart failure, renal failure) when compared with adult-onset TAK.
Study context
- Population
- Patients with TAK in observational cohort studies; databases searched up to August 20235 studies
- Participants
- 151 vs 499
- Comparison
- Pediatric-onset TAK vs adult-onset TAK
- Pediatric-onset TAKn = 151
- Adult-onset TAKn = 499reference
- Outcome
- Mortality (risk of death)
Methodological detailsmeta-regression, sub-group analyses, Five studies, all of moderate or high quality on the Newcastle Ottawa scale
- Meta-regression
- Sub-group analyses
- Five studies, all of moderate or high quality on the Newcastle Ottawa scale
Pooled result
Death
Pooled relative risk
2.27
95% CI 1.05–4.85
Pediatric-onset TAKvs Adult-onset TAK
pooled RR 2.27 (95% CI 1.05–4.85)
As reported in the abstract
Further pooled results
Causes of death
- CVD and infections were the major causes of death in both pediatric-onset and adult-onset TAK
Mortality by subgroup (study design, quality)
- Greater mortality risk with pediatric-onset TAK in retrospective (but not prospective) studies and in high-quality (but not moderate-quality) studies
Meta-regression
- No significant influence of sex distribution, age or proportions of pediatric-onset or adult-onset TAK on the pooled mortality risk
Original publication
Pediatric-onset Takayasu arteritis is associated with greater risk of mortality than adult-onset Takayasu arteritis–A systematic review with meta-analysis of observational cohort studies. Semin Arthritis Rheum. Published 22 December 2023. doi:10.
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