Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial
Authors' conclusion
This remotely delivered cognitive behavioral intervention tailored to youth with lupus was feasible and associated with reduced depressive and fatigue symptoms compared with medical TAU.
Study context
- Population
- Adolescents (12–17 years) and young adults (18–22 years) with childhood-onset SLE and elevated depressive, fatigue and/or pain symptoms; six pediatric rheumatology sites, USA and Canada, August 2020 to March 2023eligible participants randomized
- Participants
- 64 adolescents
- Comparison
- TEACH plus treatment as usual (TAU) vs TAU alone
- TEACH and TAUn = 32
- TAU alonen = 32reference
- Primary endpoint
- Feasibility and acceptability based on recruitment and retention rates
Methodological detailspilot, two-arm, multicentre
- Pilot
- Two-arm
- Multicentre
Primary result
As reported in the abstract
Feasibility: recruitment and retention
Recruitment: 97 of 200 youth approached consented
48.5%
Retention
92.2%
Further findings
Depressive symptoms (reduction in intervention group vs TAU) · postassessment (8 weeks)
- Intervention group demonstrated reduction in depressive symptoms: Cemm 7.88, 95% CI 3.20-12.60; 14%
Fatigue symptoms (reduction in intervention group vs TAU) · postassessment (8 weeks)
- Intervention group demonstrated reduction in fatigue symptoms: Cemm 3.91, 95% CI 0.44-7.39; 7%
Pain symptoms · postassessment (8 weeks)
- No reduction in pain: Cemm 0.89, 95% CI −0.06 to 1.84
Original publication
Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial. Arthritis Care Res (Hoboken). Published 20 March 2026. doi:10.
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