Premenstrual syndrome and inflammatory activity in adolescent familial Mediterranean fever
Authors' conclusion
PMS severity in adolescents with FMF appears linked to disease activity and inflammation.
Study context
- Population
- Adolescent girls (12–18 years) with Familial Mediterranean fever (FMF) and age-matched healthy controls, January 2024 to February 2025
- Participants
- 40 vs 40
- Exposure
- Adolescent girls with FMF vs age-matched healthy controls
- FMFn = 40
- Healthy controlsn = 40reference
- Outcome
- Frequency and severity of PMS (Premenstrual Syndrome Scale)
Methodological detailsage-matched healthy controls
- Age-matched healthy controls
Main finding
As reported in the abstract
- Premenstrual syndrome (PMS) frequency and severity overall lower in the FMF group
- FMF vs Healthy controls: P = 0.012
- FMF vs Healthy controls: P = 0.032
Observational data: associations, not effects.
Further findings
Correlation of PMS scores with attack frequency and Autoinflammatory Disease Activity Index (AIDAI) (FMF)
- Positive correlation of PMS scores with attack frequency and AIDAI, r
- 0.368
- P
- P = 0.019
Inflammatory markers in PMS-positive individuals (FMF)
- Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and WBC higher in PMS-positive individuals
Colchicine adherence in PMS-positive patients (FMF)
- Significantly poorer adherence in PMS-positive patients, with higher rates of forgetting doses and discontinuing colchicine
Original publication
Premenstrual syndrome and inflammatory activity in adolescent familial Mediterranean fever. Rheumatology (Oxford). Published 4 April 2026. doi:10.
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