Neurological involvement in children with familial Mediterranean fever: a systematic review
Authors' conclusion
Although causality has not been shown and reporting bias cannot be excluded, neurological involvement appears relatively common in children with FMF and may lead to long-term disability and reduced quality of life.
Study context
- Population
- Patients under 18 years diagnosed with FMF with neurological manifestations
- Participants
- 4,753 participants64 studies
- Outcome
- Neurological involvement in children with FMF
Methodological detailsPRISMA guidelines, PubMed/Medline, Cochrane and Web of Science
- PRISMA guidelines
- PubMed/Medline, Cochrane and Web of Science
Pooled result
As reported in the abstract
Some degree of neurological involvement
33.9%
Headache (most common neurological symptom, often associated with FMF flares), frequency range
4.8 to 58.8%
Febrile seizures, frequency range
1 to 15.2%
Original publication
Neurological involvement in children with familial Mediterranean fever: a systematic review. Pediatr Rheumatol Online J. Published 2 September 2025. doi:10.
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