Comparison of systemic lupus international collaborating clinics 2012 classification criteria and European league against rheumatism/American college of rheumatology 2019 classification criteria for early detection of childhood onset systemic lupus erythematosus (multi-center study)
Authors' conclusion
In this cohort among the Saudi population with childhood-onset SLE, the new EULAR/ACR 2019 criteria efficiently enable early detection of SLE, although a more frequent rate of false positives was observed with them. Escalating the total score from ≥ 10 to ≥ 13 in the cSLE population improved the specificity close to that of SLICC 2012.
Study context
- Population
- Pediatric patients up to 14 years diagnosed with SLE (cases) vs pediatric patients with other rheumatological diseases and positive ANA (≥1:80) (controls), 9 tertiary hospitals in Saudi Arabia, 2010–2021129 cases vs 116 controls
- Participants
- 245 participants
- Comparison
- SLICC 2012 vs EULAR/ACR 2019 classification criteria
- Outcome
- Sensitivity, specificity, PPV, NPV, ROC and accuracy of SLICC 2012 and EULAR/ACR 2019 criteria
Methodological detailsretrospective, multicentre, case-control
- Retrospective
- Multicentre
- Case-control
Performance
As reported in the abstract
Classification performance for cSLE
| Test or model | Sensitivity | Specificity | PPV | NPV | ROC | Accuracy |
|---|---|---|---|---|---|---|
| SLICC 2012 | 96.9% (95% CI 92.6%-99.4%) | 94.8% (95% CI 89.6%-98.32%) | 95.4% | 96.5% | 0.96 (95% CI 0.93-0.99) | 95% |
| EULAR/ACR 2019 (≥10) | 99.2% | 86.2% | 88.9% | 99.0% | 0.93 (95% CI 0.89-0.96) | 93% |
| EULAR/ACR 2019 (≥13) | 93.8% | 91.4% (85.7-96.2%) |
Sensitivity
SLICC 201296.9% (95% CI 92.6%-99.4%)
EULAR/ACR 2019 (≥10)99.2%
EULAR/ACR 2019 (≥13)93.8%
Specificity
SLICC 201294.8% (95% CI 89.6%-98.32%)
EULAR/ACR 2019 (≥10)86.2%
EULAR/ACR 2019 (≥13)91.4% (85.7-96.2%)
PPV
SLICC 201295.4%
EULAR/ACR 2019 (≥10)88.9%
EULAR/ACR 2019 (≥13)— not stated in the abstract
NPV
SLICC 201296.5%
EULAR/ACR 2019 (≥10)99.0%
EULAR/ACR 2019 (≥13)— not stated in the abstract
ROC
SLICC 20120.96 (95% CI 0.93-0.99)
EULAR/ACR 2019 (≥10)0.93 (95% CI 0.89-0.96)
EULAR/ACR 2019 (≥13)— not stated in the abstract
Accuracy
SLICC 201295%
EULAR/ACR 2019 (≥10)93%
EULAR/ACR 2019 (≥13)— not stated in the abstract
- EULAR/ACR 2019 (≥10) vs SLICC 2012: p-value of 0.86 using the Chi-squared test — no statistically significant difference
Original publication
Comparison of systemic lupus international collaborating clinics 2012 classification criteria and European league against rheumatism/American college of rheumatology 2019 classification criteria for early detection of childhood onset systemic lupus erythematosus (multi-center study). Lupus. Published 27 March 2024. doi:10.
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