Systemic lupus international collaborating clinics-2012 and European league against rheumatism/American college of rheumatology-2019 classification criteria for systemic lupus erythematosus associated with childhood-onset auto-immune cytopenia
Authors' conclusion
The SLICC 2012 and EULAR/ACR 2019 criteria do not effectively diagnose SLE in children when AIC is the predominant feature. The SLICC criteria appear to be more effective in this population of SLE patients.
Study context
- Population
- Children with childhood-onset autoimmune cytopenia (AIC) as the first manifestation of Systemic Lupus Erythematosus (SLE)
- Participants
- 79 children
- Exposure
- Systemic Lupus International Collaborating Clinics (SLICC) 2012 vs EULAR/ACR 2019 classification criteria for SLE
- Outcome
- Fulfilment of SLICC 2012 vs EULAR/ACR 2019 criteria
- Follow-up
- During
Main finding
As reported in the abstract
Criteria fulfilled
- SLICC and EULAR/ACR criteria discordant (not concomitantly fulfilled)
- 25/79 (32%)
Observational data: associations, not effects.
Further findings
Non-hematological clinical manifestations at SLE diagnosis, concordant vs discordant criteria
P = 0.004
Earlier SLE diagnosis with SLICC criteria in discordant patients
- SLICC allowed earlier diagnosis
- 16/25 (64%)
Sensitivity of EULAR/ACR criteria with maximum hematological weight of 6
- Sensitivity increased from
- 63/79 (80%)
- Sensitivity increased to
- 76/79 (96%)
Age at SLE diagnosis
- Median age at SLE diagnosis (years)
- 14.5 (1.1-21.4)
Original publication
Systemic lupus international collaborating clinics-2012 and European league against rheumatism/American college of rheumatology-2019 classification criteria for systemic lupus erythematosus associated with childhood-onset auto-immune cytopenia. Lupus. Published 22 October 2024. doi:10.
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