Ovarian dysfunction in adolescent girls with autoimmune rheumatic diseases
Authors' conclusion
Menstrual abnormalities is a common disturbance among adolescent girls with ARDs. The SLICC/ACR damage index is the main determinant for menstrual abnormalities rather than the cumulative steroid use or disease duration in JSLE.
Study context
- Population
- Adolescent girls aged 13–18 years with juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (JSLE) or juvenile dermatomyositis (JDM) classified by international classification criteria
- Participants
- 21 / 23 / 8
- Exposure
- Menstrual abnormalities across JIA, JSLE and JDM; regular vs abnormal cycles within each disease
- JSLEn = 21
- JIAn = 23
- JDMn = 8
- Outcome
- Menstrual and pubertal abnormalities
Methodological detailsdata collected from patients' files, logistic regression, Puberty and menstruation assessed by a gynaecologist with US evaluation
- Data collected from patients' files
- Logistic regression
- Puberty and menstruation assessed by a gynaecologist with US evaluation
Main finding
As reported in the abstract
Menstrual abnormalities
Observational data: associations, not effects.
Further findings
Predictors of menstrual abnormalities in JSLE (abnormal vs regular cycles)
- Median SLICC/ACR DI statistically higher in JSLE with abnormal menstrual cycles
- Cumulative steroid dose and puberty onset likewise higher
- SLICC/ACR DI the most significant predictor of menstrual abnormalities in JSLE
JIA and JDM subgroups (abnormal vs regular cycles)
- No difference in disease parameters, hormonal profile, US assessment or treatment lines
Original publication
Ovarian dysfunction in adolescent girls with autoimmune rheumatic diseases. Pediatr Rheumatol Online J. Published 14 November 2023. doi:10.
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