Juvenile dermatomyositis: association between nail fold capillary end row loop– area under the curve– and disease damage indicators
Authors' conclusion
Persistently decreased ERL capillary density, reflected by low ERL AUC, is associated with a chronic disease course and lipodystrophy in JDM.
Study context
- Population
- Initially treatment-naïve Juvenile Dermatomyositis (JDM) children observed for at least five years with multiple end row loops (ERL) density assessments
- Participants
- 68 children
- Exposure
- ERL AUC across JDM disease courses and by disease damage indicators
- Outcome
- Association of cumulative nail fold capillary ERL density (AUC) over the disease course with JDM disease damage
Methodological detailslongitudinal, at least five years of observation
- Longitudinal
- At least five years of observation
Main finding
As reported in the abstract
ERL AUC by disease course
- Chronic vs Monocyclic short: P = 0.001
- Chronic vs Monocyclic long: P = 0.013
Observational data: associations, not effects.
Further findings
Mean ERL density, treatment-naive JDM vs healthy age-matched controls
P < 0.0001
- ERL AUC by lipodystrophy · Lipodystrophy vs No lipodystrophy · lower ERL AUC with lipodystrophy
- P = 0.04
ERL AUC and calcifications or fractures
- No association between ERL AUC and calcifications or fractures
Original publication
Juvenile dermatomyositis: association between nail fold capillary end row loop– area under the curve– and disease damage indicators. Pediatr Rheumatol Online J. Published 13 November 2023. doi:10.
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