Nailfold capillary density in 140 untreated children with juvenile dermatomyositis: an indicator of disease activity
Authors' conclusion
Decreased JDM ERL density is associated with increased clinical symptoms; nailfold hemorrhages are associated with dysphagia.
Study context
- Population
- Children aged 2–17 with newly diagnosed, untreated Juvenile Dermatomyositis (JDM) and matched healthy controls; Juvenile Myositis Registryages 2–17
- Participants
- 140 vs 46
- Exposure
- Untreated JDM vs healthy controls
- Untreated JDMn = 140
- Healthy controlsn = 46reference
- Outcome
- Nailfold capillary ERL density (average of 8 fingers) and its association with disease activity
Methodological detailsage, race and sex matched healthy controls
- Age, race and sex matched healthy controls
Main finding
As reported in the abstract
Mean ERL density
P < 0.0001
Observational data: associations, not effects.
Further findings
Correlation of End Row Loop (ERL) density with disease activity scores (DAS)-skin (untreated JDM)
- R
- −0.27
- p
- P = 0.014
- Did not change within the age range tested
ERL density in untreated JDM with Myositis Specific Antibodies (MSA) Tif-1-γ
- Lowest ERL density; patterns primarily "open"
- P = 0.037
Nailfold hemorrhages and dysphagia
- Presence of hemorrhages associated with dysphagia
- P = 0.004
Original publication
Nailfold capillary density in 140 untreated children with juvenile dermatomyositis: an indicator of disease activity. Pediatr Rheumatol Online J. Published 13 October 2023. doi:10.
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