Tuberculosis among children and adolescents with rheumatic diseases - case series
Authors' conclusion
The case series demonstrated the importance of suspecting and investigating TB in RD affected patients who are using immunosuppressants/ immunobiologics, particularly in countries with high rates of TB such as Brazil.
Study context
- Population
- Children and adolescents with tuberculosis (TB) and rheumatic diseases treated at a reference center for childhood TB, Rio de Janeiro, Brazil, 1995–20228 (53%) female
- Participants
- 15 children
- Outcome
- Characteristics of children and adolescents with RD and TB
Methodological detailssingle reference centre
- Single reference centre
Main finding
As reported in the abstract
- Female
- 8 (53%)
- Mean age at rheumatic diseases (RD) diagnosis
- 7.10 years
- Mean age at TB diagnosis
- 9.81 years (SD ± 0.88 years)
- Pulmonary TB
- 9
- Extrapulmonary TB (pleural 2, joint/osteoarticular 1, cutaneous 1, ocular 1, peritoneal 1)
- 6
- GeneXpert MTB/RIF performed / detectable (no rifampicin resistance)
- 6 / 2
- Xpert Ultra performed / traces with indeterminate rifampicin resistance
- 5 / 3
Observational data: associations, not effects.
Further findings
Treatment discontinuation and death
- Discontinued treatment (one female patient)
- 1
- Died
- 1
Original publication
Tuberculosis among children and adolescents with rheumatic diseases - case series. Pediatr Rheumatol Online J. Published 10 November 2023. doi:10.
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