Clinicopathologic features in childhood-onset lupus nephritis with antineutrophil cytoplasmic antibody positivity——a multi-center retrospective study
Authors' conclusion
Positive ANCA serology in LN children was associated with different clinical and histopathologic features compared to those with negative ANCA serology.
Study context
- Population
- Children (1<age≤18 years) with lupus nephritis (LN) from three pediatric nephrology centers217 followed
- Participants
- 61 vs 330
- Exposure
- Antineutrophil cytoplasmic antibody (ANCA)-positive vs ANCA-negative childhood-onset LN
- ANCA-positiven = 61
- ANCA-negativen = 330reference
- Outcome
- Clinical and histopathologic features and renal outcomes
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Clinical and histopathologic features
- ANCA-positive
- Hematuria (urinary RBC +++ ∼ ++++) 45.9% vs 26.7%; P = 0.011
- ANCA-positive
- Fever 42.6% vs. 58.2%; P = 0.035
- ANCA-positive
- Alopecia 3.3% vs. 14.5%; P = 0.019
- ANCA-positive
- Photosensitivity 0% vs. 8.2%; P = 0.013
- ANCA-positive
- Pleurisy 4.9% vs. 15.8%; P = 0.026
- ANCA-positive
- Segmental sclerosis on biopsy 23.7% vs. 9.8%; P = 0.025
- ANCA-positive
- Crescentic formation on biopsy 36.4% vs. 16.3%; P = 0.009
- ANCA-positive
- Capillary wall thickening on biopsy 24.5% vs. 11.0%; P = 0.01
- Anti-MPO antibodies among ANCA-positive
- 86.9%
- High disease activity in both groups, median SLEDAI-2K
- 16 (13, 20)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Long-term renal survivalDid not differ significantly | P = 0.300 |
- Long-term renal survival: 217 children followed
Original publication
Clinicopathologic features in childhood-onset lupus nephritis with antineutrophil cytoplasmic antibody positivity——a multi-center retrospective study. Lupus. Published 13 April 2023. doi:10.
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