In-depth proteomic analysis of juvenile dermatomyositis serum reveals protein expression associated with muscle-specific autoantibodies
Authors' conclusion
Although JDM serum contains many proteins commonly altered in MSAs, the pathways associated with clinical features of MSAs differ based on protein accumulation.
Study context
- Population
- Patients with JDM positive for muscle-specific autoantibodies (MSAs), and healthy controls
- Participants
- 5 / 5 / 5 / 5
- Comparison
- Serum proteomes of JDM by MSA type vs healthy controls
- Anti-MDA5n = 5
- Anti-NXP2n = 5
- Anti-TIF1-γn = 5
- Healthy controlsn = 5reference
- Outcome
- Serum protein expression profiles by MSA
Methodological detailssingle-shot liquid chromatography-tandem mass spectrometry (MS) in data-independent acquisition mode, pathway analysis
- Single-shot liquid chromatography-tandem MS in data-independent acquisition mode
- Pathway analysis
Main finding
As reported in the abstract
Proteins detected from serum MS analysis
2413
Proteins commonly altered in MSAs, including many myogenic enzymes and IFN-regulated proteins
508
Original publication
In-depth proteomic analysis of juvenile dermatomyositis serum reveals protein expression associated with muscle-specific autoantibodies. Rheumatology (Oxford). Published 13 April 2023. doi:10.
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