The effect of etanercept therapy on adrenal steroid metabolism in juvenile idiopathic arthritis: a steroid metabolomics approach
Authors' conclusion
Almost all of the pre-etanercept treatment cortisol urinary metabolite levels were significantly lower than normal, and almost all rose to normal values by 1 day after treatment.
Study context
- Population
- Juvenile idiopathic arthritis (JIA) patients aged 12 ± 6.2 years with disease duration 6.3 ± 5.2 years on etanercept
- Participants
- 11 patients
- Comparison
- JIA patients before and 1 and 3 days after etanercept injection vs age- and sex-matched healthy controls
- JIAn = 11
- Outcome
- Urinary steroid metabolite levels (adrenal activity) before and after etanercept injection
- Follow-up
- Before, and 1 and 3 days after injection
Methodological detailsage- and sex-matched healthy controls, urinary steroid metabolomics (gas chromatography-mass spectrometry)
- Age- and sex-matched healthy controls
- Urinary steroid metabolomics (gas chromatography-mass spectrometry)
Main finding
As reported in the abstract
Urinary steroid metabolites low vs controls
Metabolites low before etanercept (of 31)
21
Of the 21, metabolites still low 1 day after treatment
5
Metabolites still low 3 days after treatment (2 C19, 2 C21 intermediates, α-Cortol)
5
Remaining metabolites normalised after 1 day
15
Further findings
Urinary metabolite ratios reflecting CYP21A2 and 11β-HSD2 activities
- Lower in JIA than controls, not significant
Original publication
The effect of etanercept therapy on adrenal steroid metabolism in juvenile idiopathic arthritis: a steroid metabolomics approach. Pediatr Rheumatol Online J. Published 12 April 2023. doi:10.
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