Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study
Authors' conclusion
Using a targeted multiomic approach, we clustered patients into distinct biological phenotypes that are related to disease activity state but not to organ system involvement.
Study context
- Population
- Patients with childhood-onset SLE (cSLE), preselected on disease activity state (at diagnosis, Low Lupus Disease Activity State (LLDAS), flare); healthy controls
- Outcome
- Biological phenotype clusters
Methodological detailsexplorative, unsupervised hierarchical clustering, targeted multiomics (transcriptomic and proteomic), 40-colour flow cytometry
- Explorative
- Unsupervised hierarchical clustering
- Targeted multiomics (transcriptomic and proteomic)
- 40-colour flow cytometry
Main finding
As reported in the abstract
- Three unique clusters identified, each characterised by differentially expressed genes and cytokines and by disease activity state
- 3
Original publication
Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study. Lupus Sci Med. Published 3 April 2023. doi:10.
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