Remission and low disease activity state in childhood-onset systemic lupus erythematosus: differential impact on damage accrual in a Latin American cohort (GLADEL)
Authors' conclusion
Remission but not LLDAS was associated with lower risk of new damage over 4.3 years of follow-up. None of these DAS were associated with mortality.
Study context
- Population
- Childhood-onset SLE, longitudinal inception Latin American cohort (GLADEL)84% active disease at baseline
- Participants
- 212 participants
- Exposure
- Remission and lupus low DAS (LLDAS) vs active disease
- Outcome
- New damage (increase of ≥1 point in SLICC/ACR DI), severe new damage (increase of ≥3 points) and mortality (any cause) at any time during follow-up
Methodological detailslongitudinal, Cox proportional hazards regression models
- Longitudinal
- Cox proportional hazards regression models
Main finding
As reported in the abstract
New damage
Each group vs active diseaseHazard ratio (95% CI)P value
LLDAS
0.98(0.43–2.22)
P = 0.955Remission
0.36(0.15–0.91)
P = 0.030Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Severe new damageLLDASvs Active disease | 0.40 (0.04–3.62) | P = 0.415 | |
| Mortality (any cause)Remissionvs Active disease | 0.45 (0.06–3.66) | P = 0.454 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Remission and low disease activity state in childhood-onset systemic lupus erythematosus: differential impact on damage accrual in a Latin American cohort (GLADEL). Lupus Sci Med. Published 2 July 2026. doi:10.
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