An evidence-based specialist nursing protocol for children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) and its application research
Authors' conclusion
This protocol fills the gap in specialized nursing guidelines for pediatric HLAS, standardizes clinical nursing practices, and provides a replicable methodological reference for the development of standardized nursing protocols for other rare pediatric diseases.
Study context
- Population
- Children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS); one index case admitted March 2025one index case
Methodological detailsmultidisciplinary team, retrospective case analysis, systematic literature search, thromboelastography (TEG)-based quantitative bleeding risk stratification model, Literature search of mainstream Chinese and English databases from establishment to March 2025
- Multidisciplinary team
- Retrospective case analysis
- Systematic literature search
- TEG-based quantitative bleeding risk stratification model
- Literature search of mainstream Chinese and English databases from establishment to March 2025
Main finding
As reported in the abstract
- Protocol enabled early identification of high bleeding risk, avoiding severe bleeding events and nosocomial infections in the index case
- Standardized health education and targeted psychological intervention significantly improved caregivers' disease cognition and family self-management ability
- Nurses transformed from passive caregivers to proactive care managers
Observational data: associations, not effects.
Original publication
An evidence-based specialist nursing protocol for children with hypoprothrombinemia-lupus anticoagulant syndrome (HLAS) and its application research. Lupus. Published 2 July 2026. doi:10.
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