Lupus & antiphospholipid syndrome
Validating treat-to-target endpoints in childhood lupus: data-driven sensitivity analyses from the UK JSLE cohort study
Authors' conclusion
Refining the cLLDAS definition by lowering the SLEDAI-2K cut-off to ≤3 and PGA to ≤0.25 may enhance protection against moderate-severe flare, but not new damage. No variations of cCR or cCR-0 showed significant improvement.
Study context
- Population
- Childhood-onset SLE, UK JSLE Cohort Study
- Exposure
- Varied vs original consensus-derived cSLE treat-to-target definitions
- Outcome
- Hazards of subsequent moderate-severe flare and new damage
Methodological detailsdata-driven sensitivity analyses, Prentice-Williams-Peterson (PWP) gap-time models, two-sided t-tests comparing hazard ratios (HRs)
- Data-driven sensitivity analyses
- Prentice-Williams-Peterson (PWP) gap-time models
- Two-sided t-tests comparing HRs
Main finding
As reported in the abstract
Moderate-severe flare (attainment of varied cLLDAS)
Each group vs original targetsHazard ratio (CI)P value
cLLDAS SLEDAI-2K ≤3
0.13(0.09–0.19)
P < 0.001cLLDAS PGA ≤0.25
0.14(0.10–0.20)
P < 0.001Modified cLLDAS
0.12(0.08–0.17)
P < 0.001Observational data: associations, not effects.
Further findings
New damage (Childhood Lupus Low Disease Activity State (cLLDAS) variations)
- These variations in cLLDAS did not impact on the hazards of new damage
Moderate-severe flare/new damage (cCR and cCR-0 variations)
- No variations of cCR and cCR-0 led to a significant improvement
- all P > 0.05
Original publication
Validating treat-to-target endpoints in childhood lupus: data-driven sensitivity analyses from the UK JSLE cohort study. Rheumatology (Oxford). Published 20 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →